九州工業大学大学院 生命体工学研究科

学術論文

• Moribayashi T, Nakao Y, and Ohtubo Y, Characteristics of A-type voltage-gated K⁺ currents expressed on sour-sensing type III taste receptor cells in mice. Cell Tissue Res (2024). https://doi.org/10.1007/s00441-024-03887-6
• Ueda Y, Uta D, Furue H, and Ohtubo Y, An electrophysiological method for evaluation of topical antipruritic drugs on itch-related neuronal activities in the spinal cord in hairless mice. European Journal of Pharmacology: 175798. (2023), doi: 10.1016/j.ejphar.2023.175798.
• Nakao Y, Tateno K, and Ohtubo Y, Taste receptor cells generate oscillating receptor potentials by activating G protein-coupled taste receptors. Frontiers in Physiology 13: 883372. (2022), doi: 10.3389/fphys.2022.883372
• Shigemoto M, Nakatsuka H, Ohtubo Y, Natsume K, Diurnal rhythm regulates the frequency of carbachol-induced beta oscillation via inhibitory neural system in rat hippocampus. Cognitive Neurodynamics 16(3), 507-518, 2022, doi: 10.1007/s11571-021-09736-4
• Ohtubo Y, Slow recovery from the inactivation of voltage-gated sodium channel Nav1.3 in mouse taste receptor cells. Pflugers Archiv - European Journal of Physiology 473(6), 953-968, 2021
• Takeuchi K,Yoshii K, Ohtubo Y, Age-related electrophysiological changes in mouse taste receptor cells. Experimental Physiology 106(2), 519-531, 2021
• Nakao Y, Koshimura M, Yamasaki T, Ohtubo Y, Cell-type-independent expression of inwardly rectifying potassium currents in mouse fungiform taste bud cells. Physiological Research 69, 501-510, 2020
• Ogata T, Ohtubo Y, Quantitative analysis of taste bud cell numbers in the circumvallate and foliate taste buds of mice. Chemical Senses 45(4), 261-273, 2020
• Iwamoto M, Takashima M, Ohtubo Y, A subset of taste receptor cells express biocytin-permeable channels activated by reducing extracellular Ca²⁺ concentration. European Journal of Neuroscience 51(7), 1605-1623, 2020
• Tateno K, Shiku O, Ohtubo Y, Counting algorithm for sequential optical images of immunoreactive mouse taste bud cells. ICIC Express Letters 14(1), 1-8, 2020
• 大坪義孝, マウス味蕾細胞に発現する電位依存性チャネルおよび神経伝達物質受容体, 日本味と匂学会誌　25巻１号, 25-34, 2018
• Mori Y, Eguchi K, Yoshii K, Ohtubo Y, Selective expression of muscarinic acetylcholine receptor subtype M3 by mouse type III taste bud cells. Pflugers Archiv 468(11), 2053-2059, 2016
• Yoshii K, Ohtubo Y, Kumazawa T, Neurophysiology of mammalian taste receptors. Journal of Life Science Research 13, 5-8, 2015
• Kasahara K, Ohtubo Y, Kumazawa T, Yoshii K, Neural impulse amplitude of taste nerve fiber branches depends on taste receptor sites in bullfrogs. Journal of Life Science Research 12, 9-14, 2014
• 吉井清哲，熊澤隆，大坪義孝, 味覚情報処理におけるタイトジャンクションと浸透圧の役割，生物物理，316 (54-6)，2014
• Mashiyama K, Nozawa Y, Ohtubo Y, Kumazawa T, Yoshii K, Time-dependent expression of hypertonic effects on bullfrog taste nerve responses to salts and bitter substances. Brain Research 1556, 1-9, 2014
• Kimura K, Ohtubo Y, Tateno K, Takeuchi K, Kumazawa T, Yoshii K, Cell-type-dependent action potentials and voltage-gated currents in mouse fungiform taste buds. European Journal of Neuroscience 39(1), 24-34, 2014
• Ohtubo Y, Iwamoto M, Yoshii K, Subtype-dependent postnatal development of taste receptor cells in mouse fungiform taste buds. European Journal of Neuroscience 35(11), 1661-1671, 2012
• Beppu N, Higure Y, Mashiyama K, Ohtubo Y, Kumazawa T, Yoshii K, Hypertonicity augments bullfrog taste nerve responses to inorganic salts. Pflugers Archiv 463(6), 845-851, 2012
• Ohtubo Y, Yoshii K, Quantitative analysis of taste bud cell numbers in fungiform and soft palate taste buds of mice. Brain Research 1367, 13-21, 2011
• Takeuchi K, Seto Y, Ohtubo Y, Yoshii K, Dye-permeable, voltage-gated channel on mouse fungiform taste bud cells. Brain Research 1373, 17-24, 2011
• Tateno K, Igarashi J, Ohtubo Y, Nakada K, Miki T, Yoshii K, Network model of chemical-sensing system inspired by mouse taste buds. Biological Cybernetics 105(1), 21-27, 2011
• 大坪義孝, 哺乳類味蕾細胞の電位依存性Naチャネル, 日本味と匂学会誌　17巻１号, 21-27, 2010
  

学会発表

• 嘉悦勝博, 中尾吉貴, 中川裕之, 大坪義孝, 甘味刺激によるバイオサイチン取込味細胞数の定量的解析,第101回 日本生理学会大会, 予稿集 3P-037, ３月28-30日, 小倉, 日本, 2024
• Kaetsu K, Takahashi N, Nakao Y, Nakagawa H, and Ohtubo Y, A quantitative study of biocytin-labeled taste cell numbers in response to taste substances or high-K concentration, The 57th Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 66, A-06, September 11-13, Tokyo, Japan, 2023
• Shigemoto M, Ohtubo Y, and Natsume K, The carbachol-induced beta oscillation causes the decrease in frequency by disinhibition at the midnight phase, Neuro2021 (Online), July 28-31, 2021
• 重本 昌也，大坪 義孝，夏目 季代久，ラット海馬におけるカルバコールベータ振動の概日調節メカニズムには抑制性神経が関与している, MEとバイオサイバネティクス研究会, 信学技報 IEICE Technical Report MBE2021-10, p10-15, オンライン, 6月25日, 2021
• Shigemoto M, Ohtubo Y, and Natsume K, Circadian / diurnal modulation of carbachol-induced beta oscillations in rat hippocampal slices, Neuro2020 (Online), July 29-Augst 1, 2020
• 重本 昌也，大坪 義孝，夏目 季代久，カルバコール誘導β振動周波数の概日調節と抑制性神経機構の関連性，非線形問題研究会、信学技報 IEICE Technical Report NLP2020-10, p49-54, オンライン, ５月15日, 2020
• Ohtubo Y and Miyazaki A, Immunohistostaining and Ca²⁺-imaging of tracheal solitary chemosensory cells in mice. The Journal of Physiological Sciences, Proceedings of the 97th Annual Meeting of the Physiological Society of Japan, Volume 70, Supplement 1, S98, 1P-040, March 17-19, Beppu, Japan, 2020
• 重本 昌也，大坪 義孝，夏目 季代久，ラット海馬スライスへのカルバコール投与により誘導される脳波様振動の概日調節機構，2019年度文部科学省新学術領域研究 学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会プログラム・抄録集，p14，琵琶湖ホテル, 2月4-5日, 2020
• Nakao Y, Koshimura M, Yamasaki T, and Ohtubo Y, Inwardly rectifying potassium channels in mouse fungiform taste bud cells, International Symposium on Applied Science 2019, Progranm and abstract, p 24, October 18-20, Ho Chi Minh City, Vietnam, 2019
• Aiko Miyazaki and Ohtubo Y, Immunoreactivity and Ca²⁺-imaging of solitary chemosensory cells in mouse trachea, The 53rd Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 92, P-050, September 17-19, Kochi, Japan, 2019
• Lanying Liu and Ohtubo Y, Expression of Tas1Rs and Tas2Rs genes in mouse trachea and hippocampus, The 53rd Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 92, P-049, September 17-19, Kochi, Japan, 2019
• Ohtubo Y,Nakao Y, Koshimura M, Yamasaki T, Inwardly rectifying potassium channels in mouse fungiform taste bud cells.  The 52nd Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 93, P-064, October 29-31, Omiya, Japan, 2018
• Ohtubo Y, Voltage-gated channels and neurotransmitter receptors in mouse taste bud cells.  The 51th Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 64, 研究奨励賞, September 25-27, Kobe, Japan, 2017
• Moribayashi T, Ohtubo Y, Electrophysiological properties of A-type potassium currents in mouse fungiform taste bud cells.  The 51th Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 96, P-023, September 25-27, Kobe, Japan, 2017
• Tateno K, Shiku O, Ohtubo Y, Counting algorithm for sequential optical images of immunoreactive mouse taste-bud cells. 3rd International Conference on Computational Methods in Engineering and Health Sciences (ICCMEH2016), A-4 14, Kitakyushu, Japan, 2016
• 松永絵理香、大坪義孝, マウス舌部位における味情報伝達に関する遺伝子発現の定量的解析, 第67回西日本生理学会 予稿集, p19, レインボー桜島, 2016
• Ohtubo Y, Takashima M, Electrophysiological study on ATP-permeable voltage-gated ion channels in type II cells of mouse taste bud cells. 10th Federation of European Neuroscience Societies (FENS), Programme book, p 128, D001, July 2-6, Copenhagen, Denmark, 2016
• Ogata T, Ohtubo Y, Numerical studies on the expression of cell-type marker proteins in mouse foliate and circumvallate taste buds. 17th International Symposium on Olfaction and Taste (ISOT2016), Program and Abstracts, p 129, P2-097, June 5-9, Yokohama, Japan, 2016
• Ohtubo Y, Electrophysiological properties of neurons derived from human iPS cells. The Journal of Physiological Sciences, Proceedings of the 93rd Annual Meeting, Volume 66, Supplement 1, S95, 1P-010, Maech 22-24, Sapporo, Japan, 2016
• Iwamoto M, Ohtubo Y, Quantitative and pharmacological analyses of biocytin-labeled cell numbers in single mouse taste buds.  The 49th Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 78, P-019, September 24-26, Gifu, Japan, 2015
• Ogata T, Ohtubo Y, Numerical analyses on the expression of cell type marker proteins in mouse foliate taste buds.  The 49th Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 77, P-018, September 24-26, Gifu, Japan, 2015
• Takashima M, Ohtubo Y, Effects of hemi-channel blockers to Cs-insensitive outward currents on mouse taste bud cells.  The 49th Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 77, P-017, September 24-26, Gifu, Japan, 2015
• Ogata T, Ohtubo Y, Numerical studies on the expression of cell type marker proteins in mouse circumvallate taste buds. The 48th Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 70, P-020, October 2-4, Sizuoka, Japan, 2014
• Ohtubo Y, Ogata T, Density of taste receptor cell types in mouse circumvallate taste buds. ECRO XXIVth Congress, Abstract book p223, P51, Dijon, France, 2014
• Higure Y, Ohtubo Y, Yoshii K, Aging-dependent changes in the ratio between taste receptor cells in ~20-month-old mice. FENS Featured Regional Meeting, Final Programme p50, PI-D-103, Prague, Czech Republic, 2013
• Ohtubo Y, Hashiguchi Y, Yamasaki T, Yoshii K, Postnatal development of taste receptor cells in mouse soft palate taste buds.  FENS Featured Regional Meeting, Final Programme p50, PI-D-104, Prague, Czech Republic, 2013
• Tateno K, Ohtubo Y, Kimura K, Takeuchi K, Kumazawa T, Yoshii K, Action potential shapes for a change in TEA-insensitive current ratio in mouse taste bud cell model.  FENS Featured Regional Meeting, Final Programme p50, PI-D-105, Prague, Czech Republic, 2013
• Takeuchi K, Ohtubo Y, Yoshii K, Aging effects on electrophysiological properties of taste receptor cells in ~20-month-old mice.  FENS Featured Regional Meeting, Final Programme p50, PI-D-106, Prague, Czech Republic, 2013
• Ohtubo Y, Hashiguchi Y, Yamasaki T, Yoshii K, Postnatal development of taste buds in mouse soft palates. The 47th Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 86, P-011, September 5-7, Sendai, Japan, 2013
• Tateno K, Shiku O, Ohtubo Y, Automatic counting algorithm for immunoreactive mouse taste-bud cells. The 47th Annual Meeting of the Japanese Association for the Study of Taste and Smell, Program and Abstracts, p 116, P-085, September 5-7, Sendai, Japan, 2013
• Ohtubo Y, Takeuchi K, Yoshii K, Aging of voltage-gated currents in mouse fungiform taste bud cells. The Journal of Physiological Sciences, Proceedings of the 90th Annual Meeting, Volume 63, supplement 1, p S253, 3PK-079, March 27-29, Tokyo, Japan, 2013
• Ohtubo Y, Yoshii K, Cell type dependence of voltage-gated sodium channel currents in fungiform taste bud cells. 8th FENS Forum of Neuroscience, Programme p184, Barcelona, Spain, 2012
• Yoshii K, Kimura K, Ohtubo Y, Kumazawa T, Action potentials and voltage-gated currents of mouse taste bud cells. 8th FENS Forum of Neuroscience, Programme p184, Barcelona, Spain, 2012
• Kumazawa T, Mashiyama K, Ohtubo Y, Yoshii K, Bullfrog taste nerve responses under hyperosmotic conditions. 8th FENS Forum of Neuroscience, Programme p184, Barcelona, Spain , 2012
• Tateno K, Ohtubo Y, Synchronization in the taste bud-inspired sensor network. Proceedings of 2012 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing (NCSP2012), pp507-510, Hawaii, USA, 2012
• Ohtubo Y, Iwamoto M, Yoshii K, Postnatal development of taste bud cells in mouse fungiform papillae. 8th International Brain Research Organization (IBRO) World congress of neuroscience, Program book p118, C242, Florence, Italy, 2011
• Mori Y, Ohtubo Y, Yoshii K, Selective expression of a muscarinic acetylcholine receptor M3 on type III cells in mouse fungiform taste buds. 8th International Brain Research Organization (IBRO) World congress of neuroscience, Program book p118, C240, Florence, Italy, 2011
• 大坪義孝、岩本正史、吉井清哲, マウス茸状乳頭味蕾の成長に伴う変化, 日本味と匂学会第45回大会 Abstracts, p81, 石川県立音楽堂, 2011
• Ohtubo Y. Yoshii K, The number of taste bud cells that belongs to each cell type is in equilibrium in fungifrom and soft palate taste buds of mice. 20th congress of the European chemoreception research organization, abstracts book p171, P 118, Avignon, France, 2010
• Takeuchi K, Seto Y, Ohtubo Y, Yoshii K, Pharmacology and expression of a dye-permeable voltage-gated channel on mouse taste bud cells. 20th congress of the European chemoreception research organization, abstracts book p126, P 27, Avignon, France, 2010
• 竹内啓太、瀬戸泰尚、大坪義孝、吉井清哲, マウス味蕾細胞に発現する色素透過性イオンチャネルの性質, 日本味と匂学会第44回大会 Abstracts, p64, 北九州市, 2010
• 大坪義孝, マウス味蕾細胞のsingle cell RT-PCR, 第12回　ブレインサイエンス研究会　p11、北九州市, 2010